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Berlin 2008 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 2: Medical Physics: Magnetic Resonance, Ultrasound, Dosimetry

ST 2.4: Talk

Monday, February 25, 2008, 14:00–14:15, H 2033

Non-invasive observation of 14N18O in exhaled air — •Christoph Mitscherling, Christof Maul, and Karl-Heinz Gericke — Technische Universität Braunschweig, Institut für Physikalische und Theoretische Chemie, Abteilung Laserchemie, Hans-Sommer-Straße 10, 38106 Braunschweig

Laser-induced fluorescence (LIF) spectroscopy is an extremely sensitive method for the investigation of low nitric oxide (NO) concentrations. LIF enables non-invasive and isotope-selective detection of NO in various biological environments. The excitation of the gamma-band provides fluorescence of A2Σ+(v′=0,J′)—→ X2ΠΩ(v″≥ 2,J″) around 247 nm. This method has been used for online detection of exhaled 14N16O and 15N16O [1].
In a (1+1) resonance enhanced multi-photon ionization (REMPI) time-of-flight mass spectrometer experiment the different NO isotopologues have been investigated separately to find 14N18O transitions not interfered with others. These transitions have been investigated further by the LIF device. The combination of LIF and a breath mask provides online exhaled air measurements of 14N18O with a maximum time resolution of 20 ms. The detection limit for 14N18O is about 6 ppt.

[1] Mitscherling, C. et al.: J. Breath Res. 1 (2007) 026003

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