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SYSA: Symposium Tayloring Organic Interfaces: Molecular Structures and Applications

SYSA 5: Poster Session SYSA

SYSA 5.89: Poster

Dienstag, 26. Februar 2008, 14:30–20:00, Poster A

Crystallisation of acetaminophen in nanoporous glasses — •Gopalakrishnan T. Rengarajan, Dirk Enke, and Mario Beiner — Naturwissenschaftliche Fakultät II, Martin-Luther-Universität Halle-Wittenberg, 06099 Halle/Saale, Germany

Pharmaceuticals are polymorphic materials existing in different crystalline forms like many other small molecules. Selection of a particular crystalline form and stabilization of amorphous pharmaceuticals are important issues for specific drug applications. DSC and X-ray scattering methods are used to study the crystallization behavior of acetaminophen used as model drug in nanoporous glasses with well defined pore diameters in the range 4-100nm. We will show that nanoconfinement is a strategy to produce the metastable form III of acetaminophen, which is usually inaccessible in bulk samples. Thermodynamic quantities like melting temperature and heat of melting of form III are reported for the first time [1]. We will also show that nanoconfinement can be used to increase the life time of the amorphous phase, which has better solubility and bioavailability compared to crystalline states. Thermodynamic, nucleation and kinetic effects contributing to changes in the crystallization behaviour in nanoscopic host systems will be discussed.
M. Beiner, G.T. Rengarajan, S. Pankaj, D. Enke, M. Steinhart, Nano Letters 7 (2007) 1381-1385.