Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 1: Dynamic Processes and Pattern Formation

BP 1.8: Talk

Monday, March 23, 2009, 12:30–12:45, HÜL 186

Dynamics of Blood Disorders — •Arne Traulsen¹, Jorge M. Pacheco², and David Dingli³ — ¹Max-Planck-Institute for Evolutionary Biology, 24306 Plön, Germany — ²App. Theor. Phys.-Group & Centro de Física Teórica e Computacional, Departamento de Física da Faculdade de Ciências, Complexo Interdisciplinar da Universidade de Lisboa, P-1649-003 Lisboa Codex, Portugal — ³Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Blood formation is characterized by a hierarchical architecture, with a small number of stem cells at the highest level. These cells differentiate more and more until they form the huge number of blood cells in the circulating blood. Based on a simple mathematical model for this hierarchy [1], we address the dynamics of different blood disorders. The leads to analytical estimates of the survival time of mutations in the system [2,3]. For chronic myeloid leukemia, the framework allows to describe the origin, development, response to therapy, and relapse after termination of therapy [4]. The resulting dynamics consistent with the available clinical data.

[1] D. Dingli, A. Traulsen, and J.M. Pacheco,PLoS One 2, 345 (2007) [2] D. Dingli, J.M. Pacheco, and A. Traulsen, PRE 77, 021915 (2008) [3] A. Traulsen J.M. Pacheco, and D. Dingli, Stem Cells 25, 3081 (2007) [4] D. Dingli, A. Traulsen, and J.M. Pacheco, Clinical Leukemia 2, 133 (2008)