Dresden 2009 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 16: Stochastic Processes
BP 16.4: Vortrag
Mittwoch, 25. März 2009, 16:45–17:00, ZEU 260
Polymerization of actin and cooperative ATP hydrolysis — •Xin Li1, Jan Kierfeld2, and Reinhard Lipowsky1 — 1MPI of Colloids and Interfaces, Science Park Golm, 14424 Potsdam — 2TU Dortmund, Fakultät Physik, 44221 Dortmund
Actin polymerization plays an important role in many aspects of cell dynamics. Actin polymerization also involves the hydrolysis of ATP molecules, which takes place within an ATP-rich cap and can be spatially separated from the polymer tip. In this study, we theoretically compare different cooperative mechanisms for the coupling between ATP hydrolysis and actin polymerization and describe their effects on experimentally observable quantities, such as cap length, total hydrolysis rate, and actin filament growth rate.