Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 17: Poster II

BP 17.18: Poster

Wednesday, March 25, 2009, 17:15–19:45, P3

Protein translocation across artifical membrane channels — •Stefan Bommer and Patrick Huber — Technische Physik, Universität des Saarlandes, Saarbrücken

Protein translocation across biological membranes is a fundamental process in cell biology. Many qualitative and semi-quantitive aspects of the translocation process have been analyzed over the last 35 years. The bacterial plasma membrane, the membrane of the endoplasmic reticulum, the inner and outer membranes both of mitochondria and chloroplasts all contain protein translocons. They all have one structural feature in common: a narrow aqueous channel as central subunit.

To better understand the collective, physical mechanisms of protein transport across bio-membranes we performed rigorous experimental protein permeation experiments through artificial, tunable channels in solid-state membranes using folded and unfolded cytochrome c supported by Brownian-Dynamics-Simulations that mimic the experimental geometry.