Dresden 2009 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Poster II
BP 17.1: Poster
Mittwoch, 25. März 2009, 17:15–19:45, P3
Elastic properties of human cancer cells — •Carsten Hentschel1, Hendrik Hölscher2, Stefan Schneider2, and Kristina Riehemann1 — 1Center for Nanotechnolgy (CeNTech)/University of Münster, Heisenbergstraße 11, 48149 Münster — 2Affilitation
In the past decade the analysis of biomechanical properties of cancer cells became a tool to determine the invasiveness of a tumor. Atomic force microscope (AFM) has developed to a powerful tool to measure biophysical parameters by using force spectroscopy on living cells in liquid. The force spectroscopy in contact mode can be applied to gain more information about the structure and physical properties (e.g. elasticity) of cells. Different approaches have been shown to get this information [1]. But reproducible results in this area remains to be scarce
We optimized existing methods and showed highly reproducible results demonstrating the elasticity of different celllines strongly correlated to their invasiveness making this methods usefull for clinical applications.
[1] Acta Biomaterialia 3, S. Suresh, 413- 438 (2007)