Dresden 2009 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Poster II

BP 17.29: Poster

Mittwoch, 25. März 2009, 17:15–19:45, P3

Theoretical simulation of Protein Kinase C (PKC) membrane translocation — •Mike Bonny, Martin Peglow, Karsten Kruse, and Heiko Rieger — Universität des Saarlandes, Theoretische Physik

Conventional protein kinases C (cPKCs) play an essential role in signal transduction and in gene regulation. PKCα, a member of the cPKC-family, translocates to the plasma membrane after activation via Ca²⁺-ions in cytoplasm and creates local pattern, so-called local translocation events, with limited spatial spreads (<4 µ m), comprising two groups of lifetimes; brief events (400−1500 ms) and longlasting events(>4 s).

In our work, we use a mean-field description as well as a three dimensional stochastic reaction-diffusion model. If on assumes interactions among the PKCα molecules in the membrane both models show similar results and are able to explain the two groups of lifetimes and the limited spatial spread of membrane-bound PKCα molecules.