Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 17: Poster II

BP 17.30: Poster

Wednesday, March 25, 2009, 17:15–19:45, P3

Inflammatory activation of macrophages by specific kinds of nanoparticles — •Kristina Riehemann¹, Kathrin Hardes¹, Stefan Gerbes², and Mirko Bukowski² — ¹Center for Nanotechnolgy (CeNTech)/University of Münster, Heisenbergstraße 11, 48149 Münster — ²INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbruecken, Germany

Nanoparticles (NP) find more and more their way to clinical applications. Unfortunately negative side effects may happen e.g. through the activation of the immune system through complementary activation or by generation of autoimmune diseases. Macrophages are involved in the innate immunity of the body. Their reaction on NP is important for further acceptance of the particles by the immune system. We investigated the interaction of NPs with primary cell cultures of macrophages derived from peripheral blood and different kinds of macrophage cell-lines. The synthesised NP we used where SiO2- Particles which differed in size, surface charge and *chemistry. Some particles where modified with polyethyleneglycole(PEG)-chains on their surface. We have shown that dependent on their surface structure NP can activate macrophage as shown by the secretion of inflammation mediators like IL1, iNOS and H2O2.