Dresden 2009 – scientific programme
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BP: Fachverband Biologische Physik
BP 17: Poster II
BP 17.41: Poster
Wednesday, March 25, 2009, 17:15–19:45, P3
Modeling of spatio-temporal dynamics in glycolysis with inhomogeneous periodic influx of substrate — •Anastasia Lavrova1, Eugene Postnikov2, Thomas Mair3, and Lutz Schimansky-Geier1 — 1Institute of Physics, Humboldt-University at Berlin, Berlin, Germany — 2Department of Theoretical Physics, Kursk State University, Kursk, Russia — 3Institute of Experimental Physics,Otto-von-Guericke-University Magdeburg, Germany
Spatio-temporal dynamics in glycolysis has been observed in the yeast extracts. It has been shown that waves can be induced by local perturbation on the activity of key enzyme, phosphofructokinase (PFK). [Bagyan et al, 2005]. Since the propagation dynamics and shape of traveling reaction-diffusion waves can contain information about the state of the system, it has been suggested that they can play an important role for biological information processing [Mair et al,2000].
In the present work we consider the Selkov model extended with diffusion terms which describes glycolytic phase waves observed in yeast extracts. It has been shown that the slightly non-uniform influx can provide a rich assortment of wave patterns such a traveling waves with a phase reversal, spatial-temporal beats, etc. With the introduction of non-stationary periodic influx it is possible to control the direction and the velocity of waves.
We discuss mechanisms of the waves propagation depending on the inhomogeneous periodic substrate influx.