Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 19: Cell Adhesion

BP 19.2: Talk

Thursday, March 26, 2009, 11:00–11:15, ZEU 260

Adhesion Dynamics of Early Cell Spreading — •Pavel Ryzhkov, Christina Oettmeier, Jac-Simon Kühn, Marcus Prass, and Hans-Günther Döbereiner — Institut für Biophysik, Universität Bremen

We report on the adhesion dynamics of spreading mouse embryonic fibroblasts. Advancing membrane edges and adhesions patterns on two-dimensional substrates are characterized by reflection interference contrast microscopy. We observe spatial-temporal correlations of early spreading events. Adhesion commences via the recurring appearance and disappearance of small patches. These patches grow slowly in size and lifetime until a continuous adhesion patch has formed, which initiates fast cell spreading.