Dresden 2009 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 4: Cell Mechanics

BP 4.9: Vortrag

Montag, 23. März 2009, 16:45–17:00, HÜL 186

Optical Cell Stretching and Cell Squeezing — •Tobias Kiessling, Franziska Wetzel, Karla Müller, Anatol Fritsch, K. David Nnetu, and Josef Käs — University of Leipzig

Rheological measurements on single cells are in general considered to be important for the understanding of living organisms. Determined by the cytoskeleton, the mechanical response provides an insight to the molecular structure and reflects the healthiness of each single cell. For biomechanical measurements, the Optical Cell Stretcher, a tool generating optical surface forces on single cells is of great importance since it provides a noninvasive access to the viscoelastic behavior of about 100 single cells per hour. The induced surface forces tend to stretch the cell and by applying optically induced step-stress experiments on single cells, an intimately relation between deformability and malignancy is revealed. With a slight change of setup paramters optical surface forces can be redistributed leading to a squeezed-like deformation instead of a stretch, and enabling various applications such as frequency dependent single cell rheology.