DPG Phi
Verhandlungen
Verhandlungen
DPG

Dresden 2009 – scientific programme

Parts | Days | Selection | Search | Downloads | Help

BP: Fachverband Biologische Physik

BP 5: Proteins

BP 5.2: Talk

Monday, March 23, 2009, 14:45–15:00, ZEU 260

The Kinetics and Structure of Protein Energy LandscapesMichael Prentiss1, •David Wales2, and Peter Wolynes11University of California, San Diego USA — 2Cambridge University, UK

The complexity of the physical interactions that guides the folding of biomolecules presents a significant challenge for atomistic modeling. Minimal representation protein structure prediction potentials have previously been used to predict protein structure from sequence. The resulting landscapes suggests the actual protein energy landscapes are funneled as predicted from theory. We show how basin-hopping global optimisation can identify low-lying minima for the corresponding mildly frustrated energy landscapes. Further more we calculate several disconnectivity graphs for the folding reaction a protein using a database of minima and transition states. Using these databases we calculate the diffusion of the polypeptide change as a function of an native contacts.

100% | Mobile Layout | Deutsche Version | Contact/Imprint/Privacy
DPG-Physik > DPG-Verhandlungen > 2009 > Dresden