Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 7: Poster I

BP 7.20: Poster

Monday, March 23, 2009, 17:45–20:00, P3

Imaging microtubule modulating proteins with atomic force microscopy — •Karen Hollenberg, Florian Hagene, Iwan A. T. Schaap, and Christoph F. Schmidt — 3. Physikalisches Institut, Fakultät für Physik, Georg-August-Universität, 37077 Göttingen

Microtubules have the most complex structure of the filaments forming the cytoskeleton and show alternating phases of growth and shrinkage. These microtubule dynamics are regulated by a variety of microtubule stabilizing and destabilizing proteins that allow the cytoskeleton to adapt to the needs of the cell.

We have set out to use atomic force microscopy in buffer to study how and where such stabilizing proteins bind to the microtubule lattice and compare this to the binding patterns of kinesin motor proteins at a single protein resolution.