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Dresden 2009 – scientific programme

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BP: Fachverband Biologische Physik

BP 7: Poster I

BP 7.32: Poster

Monday, March 23, 2009, 17:45–20:00, P3

The mechanisms of lipid membrane-induced IAPP fibrillogenesis and its inhibition — •Sebastian Tiemeyer1, Florian Evers1, Christoph G. Jeworrek2, Michael Paulus1, Bernd Struth3, Metin Tolan1, and Roland Winter21Faculty of Physics / DELTA, TU Dortmund, 44221 Dortmund, Germany — 2Faculty of Chemistry, TU Dortmund, 44221 Dortmund, Germany — 3Deutsches Elektronen-Synchrotron, HASYLAB, Notkestr. 85, 22607 Hamburg, Germany

Protein misfolding plays an important role in many diseases like Alzheimer's, Parkinson's or type 2 diabetes mellitus. In the latter case, IAPP is thought to cause the death of insulin-producing beta-cells in the pancreatic islets of Langerhans. Previous experiments propose aggregation of IAPP to amyloid fibrils at beta-cell membranes followed by membrane disruption. X-ray reflectivity (XRR) experiments were performed at the beamline BW1 at HASYLAB in order to investigate the IAPP - lipid membrane interaction in the presence and absence of the red wine compound resveratrol. From the XRR data, we were able to identify the status of nucleation, aggregation and fibrillation of IAPP at the lipid membrane interface. Furthermore, the inhibition of the aggregation process by resveratrol was revealed.

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