Dresden 2009 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 25: Diffusion and Dynamics

CPP 25.7: Talk

Wednesday, March 25, 2009, 17:00–17:15, ZEU 160

Single molecule studies of mesoporous silica structures for drug-delivery applications — •Timo Lebold, Christophe Jung, Thomas Bein, Jens Michaelis, and Christoph Bräuchle — Center for Nanoscience (CeNS) and Nanosystems Initiative Munich (NIM), Ludwig-Maximilians-Universität München, Department of Chemistry and Biochemistry, Butenandtstraße 11, 81377 München

Novel drug-delivery systems based on nanostructures can provide fundamental progress to many therapies in medicine. We apply mesoporous thin silica films with nanometer-sized pores as drug carriers and incorporate the anti-cancer drug Doxorubicin. The measurements conducted on a single-molecule level provide insights into mechanistic details of the diffusion process. The diffusion dynamics of the drug inside the host channel system is controlled and modified. Further, the release kinetics of the drug is determined and live-cell measurements prove the applicability of the system for drug-delivery. This study demonstrates the high potential of nanoscience for medicine.