Dresden 2009 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 8: Nanoparticles I

CPP 8.6: Vortrag

Montag, 23. März 2009, 11:45–12:00, ZEU 114

Size-controlled functionalized magnetite nanoparticles and their cellular uptake — •Sebastian Weibels¹, Anja Sommer¹, Stefanie Klein¹, Jessica Ploettner¹, Klaus Gieb², Konstantin Petukhov², and Carola Kryschi¹ — ¹Dept. Chemistry and Pharmacy, Physical Chemistry I, FAU, Egerlandstr. 3, 91058 Erlangen — ²Physical Institute III, FAU, Erwin-Rommel-Str. 1, 91058 Erlangen

Magnetite nanoparticles (MNP) were synthesized by coprecipitating Fe(II)/Fe(III)solutions with an ammonia solution, and their sizes were tuned between 4 and 15 nm by varying the concentrations of the reactants. Repulsive interactions between the MNP and their solubility in polar and unpolar solvents were obtained by functionalizing the MNP with suited organic acids. FTIR spectra of successfully functionalized MNP indicate covalent binding via the carboxylic group. The MNP sizes were determined under a high-resolution transmission electron microscope, while the magnetic properties in dependence on temperature were investigated using a SQUID magnetometer. The uptake of functionalized MNP by Caco-2 cells were imaged by transmission electron microscopy.