Dresden 2009 – wissenschaftliches Programm

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DY: Fachverband Dynamik und Statistische Physik

DY 2: Statistical physics in biological systems I (joint session DY/BP)

DY 2.3: Vortrag

Montag, 23. März 2009, 11:30–11:45, ZEU 255

Stochastic models for efficient intracellular transport — •Maximilian Ebbinghaus and Ludger Santen — Department of Theoretical Physics, Saarland University, 66041 Saarbruecken

Intracellular transport along microtubules is bidirectional although single motor proteins such as kinesin or dynein perform stochastic motion in a single direction. For several diseases, the breakdown of the bidirectional transport is known to be pathologic. It is thus of great importance to understand how cells organize their transport system in an efficient way and which influences might interfere. We approach this question by numerically examining one-dimensional lattice gas models with multiple filaments in parallel on which we assume hard core exclusion. Further particle-particle interactions are introduced in order to observe lane formation, i.e. filaments that are occupied by a single type of molecular motor. In this way, we find different transport regimes with highly different transport capacities. The surrounding cytoplasm is modeled by further tracks on which particles do not interact and perform undirected diffusion. This very simplified model of the cytoplasm is compared with the results of a model with similar dynamics on the filaments but in a three-dimensional cylinder.