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SYSO: Symposium Self-organizing Surfaces and Interfaces

SYSO 5: Self-Organizing Surfaces and Interfaces IV

SYSO 5.1: Vortrag

Donnerstag, 26. März 2009, 11:00–11:15, GÖR 226

Establishment and Maintenance of Compartment Boundaries in Growing Tissues — •Jonas Ranft¹, Reza Farhadifar¹, Katharina Landsberg², Thomas Bittig¹, Christian Dahmann², and Frank Jülicher¹ — ¹Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany — ²Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, 01307 Dresden, Germany

In many developing epithelia, which are essentially two-dimensional tissues, distinct cellular compartments emerge. Cells within a given compartment show a characteristic signature of gene expression. Boundaries between compartments are typically sharp and often straight. Furthermore, these boundaries are lineage boundaries, i.e., the progeny of a cell lies in the same compartment. Such compartment boundaries can be considered as interfaces in the tissue. We discuss the role of cell division and cell mechanics for the morphology of compartment boundaries between two cell populations. Using a vertex model which can describe cell packing geometries, we study the conditions which give rise to stable and straight compartment boundaries during growth. We find that increased cell boundary tension at the interface between two cell populations can prevent the mixing of cells and leads to sharp boundaries. In order to quantify the morphology of these interfaces, we study the scaling behavior of interface fluctuations. We quantitatively compare our simulation results with experimental observations of the anteroposterior compartment boundary in the developing wing of the fruit fly Drosophila.