Dresden 2009 – wissenschaftliches Programm

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SYSO: Symposium Self-organizing Surfaces and Interfaces

SYSO 5: Self-Organizing Surfaces and Interfaces IV

SYSO 5.4: Vortrag

Donnerstag, 26. März 2009, 11:45–12:00, GÖR 226

Min proteins make waves: Self-organization of bacterial cell division proteins in vitro — •Martin Loose^1,2, Elisabeth Fischer-Friedrich³, Christoph Herold¹, Karsten Kruse⁴, and Petra Schwille^1,2 — ¹Biophysics, Biotec, TU Dresden, Dresden, Germany — ²Max-Planck-Institute for Molecular Cell Biology and Genetics, Dresden, Germany — ³Max-Planck-Institute for Physics of Complex Systems, Dresden, Germany — ⁴Theoretische Physik, Universität des Saarlandes, Saarbrücken, Germany.

In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. We found that the Min proteins spontaneously formed planar surface waves on a flat supported membrane in vitro. We developed TIRF based single-molecule imaging experiments that revealed the dynamics of individual proteins during wave propagation.