München 2009 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 1: Measurements and Effects of Environmental Radiation Exposures
ST 1.4: Vortrag
Dienstag, 10. März 2009, 10:00–10:20, A021
Comparison of mortality and incidence cancer risk and models of genomic instability: the Techa River cohort — •Markus Eidemüller1, Zhenia Ostroumova2, Ludmila Krestinina2, Alexander Akleyev2, and Peter Jacob1 — 1Helmholtz Zentrum München, Institut für Strahlenschutz, 85764 Neuherberg — 2Urals Research Center for Radiation Medicine, Vorovsky St. 68-a, Chelyabinsk, 454076, Russia
Solid cancer mortality and incidence risk after radiation exposure in the Techa River Cohort in the Southern Urals region of Russia is analyzed. Residents along the Techa River received protracted exposure in the 1950s due to the releases of radioactive materials from the Mayak plutonium complex. The analysis is performed within the framework of the biologically based two-stage clonal expansion (TSCE) model and with excess relative risk models. TSCE models including effects of radiation-induced genomic instability are applied to the data and it is found that the best description of the radiation risk is achieved with the same model of genomic instability both for the mortality and incidence cohort. By a direct comparison of the cancer risk in both cohorts it is shown how the mortality and incidence rates and excess relative risk can be related. The TSCE parameters, that describe effective biological time scales in the process of cancer development, turn out to be similar for the mortality and incidence data sets.