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P: Fachverband Plasmaphysik
P 19: Poster: Low Temperature Plasmas II
P 19.9: Poster
Donnerstag, 11. März 2010, 16:00–18:00, Lichthof
Milieu alterations of biological surfaces by non-thermal plasma at atmospheric pressure — •Andreas Helmke1, Dennis Hoffmeister1, Nina Mertens1, Jan Schuette2, and Wolfgang Viöl2 — 1Department of Sciences and Technology, University of Applied Sciences and Arts, Von-Ossietzky-Str. 99, 37085 Goettingen, Germany — 2Laser Laboratorium Goettingen e.V., Hans-Adolf-Krebs-Weg 1, 37077 Goettingen, Germany
Although cold atmospheric plasmas (CAP) have proven their efficacy in biomedical fields like decontamination, coagulation, and wound healing, the mechanisms of interaction between plasma constituents and biological matter are still uncertain. The arrangements are often operated with ambient air due to its overall disposability and manifold reactivity. Clinical research revealed elevated pH values in chronic wounds thus leading to distorted resident microbial flora resulting in vulnerability to pathogens and inflammation which inherently prevents healing of the wound. To escape from this circle, pH-targeted therapies to affect microbial growth have been proposed.
In a general approach, we studied the acidifying efficiency of a CAP treatment and ambient air as a working gas on lipid films. Acidification of a thin water film could be observed on plasma-treated surfaces of wool wax, pork sebum and human lipid layers. This pH shift was partly attributable to NOx species and to the formation of nitric acid in the upper layers of the substrates. The acidic compounds on the lipid surfaces resulted in pH shifts for up to 2 h after plasma exposure, which might be beneficial for pH-targeted therapies in dermatology.