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SYMP: Symposium Plasma in Biology and Medicine

SYMP 1: Plasma in Biology and Medicine (SYMP)

SYMP 1.8: Hauptvortrag

Mittwoch, 10. März 2010, 18:00–18:30, A 001

Electrochemotherapy - An efficient electroporation based tumor treatment — •Damijan Miklavcic — University of Ljubljana

When cells are exposed to a sufficient high electric field, permeability of their plasma membrane is increased. This allows molecules, that otherwise can not penetrate through the membrane, to enter the cell. One of the most advanced applications taking the advantage of this phenomenon is electrochemotherapy. Electrochemotherapy is currently used in daily clinical practise for treatment of superficial tumor nodules. Electrochemotherapy as a local treatment combining cancer dugs such as bleomycin or cisplatinum with short high voltage electric pulses results in approximately 80% complete responses irrespective of histological origin of the tumor.