Regensburg 2010 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 19: Membranes and Vesicles

BP 19.6: Vortrag

Mittwoch, 24. März 2010, 11:30–11:45, H43

Influence of Additives on the Short-Time Dynamics of the Phospholipid DMPC — •Sebastian Busch and Tobias Unruh — Physik Department E13 and Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II), Technische Universität München, Lichtenbergstraße 1, 85748 Garching bei München

In nature as well as in industrial applications, phospholipid membranes contain many components which have significant influence on the properties of the membrane. A striking example is the use of sodium glycocholate (NaGC) as co-emulsifier which enhances the stability of phospholipid-stabilized emulsions by orders of magnitude.

In pharmaceutical technology, the term "fast co-emulsifier" was coined to describe the ability of NaGC to even stabilize droplets which undergo a rapid deformation due to crystallization.

On the other hand, the status-quo of the description of phospholipid membrane dynamics, the free volume theory, predicts a decrease of mobility when additives fill up voids within the lipophilic core of the membrane.

We are able to show with quasielastic neutron scattering that the addition of NaGC indeed increases the picosecond dynamics of the phospholipid DMPC. This effect is compared to the influence of lipophilic additives, namely myristic acid, farnesol, and cholesterol.