Regensburg 2010 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 20: Networks: From Topology to Dynamics I (joint DY, BP, SOE)

BP 20.2: Vortrag

Mittwoch, 24. März 2010, 10:30–10:45, H44

Reliable Boolean networks with threshold functions — •Manuel Ross, Tiago Peixoto, and Barbara Drossel — Institut für Festkörperphysik, TU Darmstadt

Boolean networks are used to model biological networks, such as gene regulatory networks. The nodes of the networks are in this case interpreted as genes, and the state is taken as activity, discretised to Boolean values. An attractor trajectory of the Boolean network is equivalent to a periodic time evolution of the respective network. The usual approach to analyzing these models consists in studying the dynamics of a given network or ensemble. The reverse approach, which we take here, is to deduce the structure of a network from dynamical properties, done for instance by Lau et al. [1]. The dynamical property considered here is a robust sequence of states, i.e., the dynamical trajectory shall not change under perturbations in the update times. We consider the extreme case where the dynamics is reliable under any update sequence, so only one node can possibly change its state at any given moment in time. Such reliable networks were introduced recently in our group [2]. We now extend this work by permitting only threshold functions as update functions. This imposes severe restrictions on the possible reliable trajectories, in contrast to the original study, where all Boolean functions were permitted. We explore the consequences of this restriction for the statistical properties of the possible dynamical trajectories. These statistical properties are finally compared to microarray data. References: [1] K. Y. Lau et al. Phys. Rev. E, 75(5):051907, 2007. [2] T. Peixoto and B. Drossel. arXiv:0905.0925v1, 2009.