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BP: Fachverband Biologische Physik

BP 21: Neurobiophysics and Sensory Transduction

BP 21.5: Vortrag

Mittwoch, 24. März 2010, 15:15–15:30, H43

When less is more: Spike Sequence Processing in Neurons with Adaptive Synapses — •Hinrich Kielblock¹ and Marc Timme^1,2 — ¹Network Dynamics Group, Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — ²Bernstein Center for Computational Neuroscience Göttingen, Germany

The input-output relation of a neuron centrally underlies the computational capabilities of neural circuits. The response of a neuron to incoming spike signals strongly depends on the relative timing of the presynaptic spikes. For example, if the input's timing is highly regular, an increase in excitatory input can lead to a decrease of the neurons firing rate. This counterintuitive phenomenon occurs in various neural systems but its underlying mechanism is still unclear.

Here we investigate single neuron systems where a neuron receives precisely timed spiking input via one depressive synapse. Our analysis reveals that and how non-monotonic input-output relations are created by a spike timing-dependent transmission efficiency.