Regensburg 2010 – scientific programme
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BP: Fachverband Biologische Physik
BP 26: From Single-Molecule to Tissue Dynamics
BP 26.10: Talk
Thursday, March 25, 2010, 16:45–17:00, H43
Compartment boundaries in developing epithelia — •Maryam Aliee1, Katharina Landsberg2, Jonas Ranft1, Christian Dahmann2, and Frank Jülicher1 — 1Max Planck Institute for the Physcis of Complex Systems, 01187 Dresden, Germany — 2Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
During the development of tissues distinct cellular compartments are established. Straight and sharp interfaces between these compartments are maintained during development, so called compartment boundaries. A fundamental question is to identify the mechanisms by which boundaries form and remain stable. An important model system to study compartments is the wing development of the fruit fly Drosophila.Two different compartment boundaries are established during the development of the wing imaginal disc, the Anterior-Posterior boundary and the Dorsal-Ventral boundary. To study the role of cell mechanics and cell division we use a vertex model. We consider two dividing populations of cells and analyze the effect of local changes of cell bond tension and cell proliferation on the morphology of compartment boundaries. We find that a straight interface is maintained between two compartments if the proliferation rate of cells near the boundary is reduced. Increased bond tension at interface also leads to sharp boundaries. We quantify cell packing properties and interface roughness and study the interfacial tension associated with the compartment boundary using the stress profile in the system.