Regensburg 2010 – scientific programme

Parts | Days | Selection | Search | Downloads | Help

BP: Fachverband Biologische Physik

BP 32: Posters: Physics of Cells

BP 32.18: Poster

Thursday, March 25, 2010, 17:15–20:00, Poster B1

Biomechanical Data Networks — •Tobias R. Kießling, Kenechukwu D. Nnetu, Anatol Fritsch, Roland Stange, and Josef A. Käs — University of Leipzig, Institute of Experimental Physics I, Linnéstr. 5, 04103 Leipzig, Germany

The transition from benign tissue to malignant cancer is accompanied by various alterations of the cellular organization, amongst others of the cytoskeleton. This highly dynamic polymer network provides both, functional and mechanical stability to cells whereas small changes of the cytoskeletal composition are reflected in alterations of the mechanical properties of cells.

The Microfluidic Optical Cell Stretcher, built to monitor these cytoskeletal changes provides a fast and easy access to a range of physical parameters of thousands of cells. Methods derived from gene expression network analysis techniques will be discussed that help to reveal unbiased relations between measured physical properties and how these can be used to differentiate between benign and malignant cells without the need of any molecular marker.