Regensburg 2010 – scientific programme
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BP: Fachverband Biologische Physik
BP 32: Posters: Physics of Cells
BP 32.49: Poster
Thursday, March 25, 2010, 17:15–20:00, Poster B1
Cells on different substrates. An investigation with AFM and optical microsopy. — •Daniele Martini1, Michael Beil2, Othmar Marti1, and Thomas Schimmel3,4 — 1Institute of exp. physics, Ulm University — 2Institute of internal medicine I, Ulm University Hospital — 3Forschungszentrum Karlsruhe — 4Karlsruhe University
The main task of epithelial cells is to form a physical barrier, which is characterized by the properties of the cytoskeleton and cell-cell contacts. The principal aim of the first part of this project is to modulate the structure of these macromolecular complexes, optimizing the mechanical properties of the cells by a spatially hierarchically ordered and t-variable nanostructured culture substrate . Thus, at first, we have to investigate and control the growing and arrangement of these cells on different surfaces and, later, to define and influence the subcellular structure with chemically nanostructured culture substrates. In this poster we show AFM and optical microscopy experiments on adherent cells on different substrates. We discuss the influence of the substrate on cell morphology and on AFM images.