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BP: Fachverband Biologische Physik

BP 5: Posters: Biopolymers and Biomaterials

BP 5.29: Poster

Montag, 22. März 2010, 17:15–20:00, Poster B1

Interaction of Boron-Clusters with liposomes : Influence on the Zeta-potential — •Aleksandre Japaridze¹, Mathias Winterhalter¹, and Detlef Gabel² — ¹School of Science and Engineering, Jacobs University Bremen, Campus Ring 1,D-28759 Bremen,Germany — ²Department of Chemistry, University Bremen, PO Box 330440, D-28334 Bremen, Germany

Boron clusters have potential for clinical use in the so-called boron neutron therapy. Therefore it is of interest to study the interaction between the clusters and the cells. In order to quantify the affinity of charged Boron cluster to lipid membranes we may use Zeta-potential measurements of liposomes. In following experiments we have been investigating the interaction of negatively charged boron-clusters with neutral POPC liposomes, focusing on the change in Zeta potential. Liposomes were used as a cell membrane model for the experiments. For example, the Zeta-potential of POPC liposomes with Na2B12I12 clusters was -47mV at pH value 7.4 .