Regensburg 2010 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 11: Poster: New Instruments and Methods

CPP 11.8: Poster

Monday, March 22, 2010, 16:30–18:00, Poster C

Concepts for magnetoresistive sensors and microfluidic integration — •Dieter Akemeier, Alexander Auge, Frank Wittbracht, Alexander Weddeman, and Andreas Hütten — Uni Bielefeld, Fakultät für Physik, Universitätsstr. 25, 33615

Point-of-care diagnostics is a rapidly growing field with the aim to miniaturize standard laboratory tests. Using magnetic point-of-care diagnostic devices has various advantages compared to other approaches like the direct read out of giant magneto resistance sensors, low interaction with biologic materials and low cost production.

The detection of antigens or bacteria in the continuous flow approach uses selective binding of magnetic markers on functionalized sensor surfaces located on the bottom of the flow channel. To position the particles on top of the sensor array a microfluidic structure of changing height is used. This increases the capture rate by more than 100% in comparison to a straight channel and leads to a homogeneous sensor coverage. By placing an array of 32 magnetoresistive sensors at certain position within the microfluidic system, it is possible to catch biomolecules from different starting heights on specified sensors. The experimental detection process will be discussed in detail and is compared with theoretical predictions.