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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 14: Poster: Interfaces and Thin Films

CPP 14.18: Poster

Montag, 22. März 2010, 16:30–18:00, Poster C

Molecularly imprinted PPy for the voltage-dependent uptake and release of L-glutamate in neutral pH — •Kathrin Fuchs, Elizabeth von Hauff, and Jürgen Parisi — University of Oldenburg, Department of Physics, Energy and Semiconductor Research Laboratory, Carl-von-Ossietzky Str. 9-11, 26129 Oldenburg, Germany

For medical or biological applications, a device, which can control the concentration of a specific biomolecule in solution, is of great interest. Therefore, polypyrrole (PPy) is analysed with respect to the voltage-dependent uptake and release of L-glutamate, an important neural transmitter in the human nervous system. Additionally the effect of glutamate diffusion out of the film is investigated.

The PPy is electrochemically deposited on Au-coated electrodes utilizing an aqueous solution containing the monomer pyrrole and sodium L-glutamate. For some examinations, the PPy was electrochemically overoxidized using a phosphate buffer solution and thereby creating glutamate selective cavities. Such overoxidized PPy films have been described as having selective properties regarding the L-conformation of glutamate at low pH [1]. In this study, the uptake and release of glutamate resulting from a voltage sweep and having a mass change of the polymer film in neutral pH solution as a consequnece is measured using an electrochemical quartz crystal microbalance (EQCM), while the diffusion of glutamate out of the polymer film is determined using UV/Vis-spectroscopy.

[1] B. Deore, Z. Chen, and T. Nagaoka, Analytical Sciences, 15, 827, 1999