Regensburg 2010 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 9: Crystallization and Self Assembly II
CPP 9.8: Vortrag
Montag, 22. März 2010, 15:45–16:00, H48
Single-Molecule Force Spectroscopy of Supramolecular Heterodimeric Capsules. — •Tobias Schröder1,2, Thomas Geisler2, Björn Schnatwinkel2, Dario Anselmetti1, and Jochen Mattay2 — 1Department of Physics, Experimental Biophysics & Applied Nanosciences, Bielefeld University, — 2Department of Chemistry, Organic Chemistry I, Universitätsstrasse 25, 33615 Bielefeld, Germany
Despite the rich information accessible, atomic-force single-molecule force spectroscopy (AFM-SMFS) has scarcely been employed to analyze the bonding between building blocks of complex supramolecular structures [1]. After the pioneering work by Eckel et al. [2], we investigated the multiple bonding interaction in a supramolecular capsule held together by four hydrogen bonds [3]. The measured dissociation forces of the heterodimeric capsule represent the mechanical stability of the supramolecular system and allow a quantitative evaluation of the interaction yielding the kinetic dissociation rate constant k(off), the reaction length x(β) and the standard Gibbs free energy ΔG0 according to the Bell-Kramers model.
[1] M. Janke, Y. Rudzevich, O. Molokanova, T. Metzroth, I. Mey, G. Diezemann, P. E. Marszalek, J. Gauss, V. Böhmer, A. Janshoff, Nat. Nanotechnol. 2009, 4, 225-229.
[2] C. Schäfer, R. Eckel, R. Ros, J. Mattay, D. Anselmetti, J. Am. Chem. Soc. 2007, 129, 1488-1489.
[3] T. Schröder, T. Geisler, B. Schnatwinkel, D. Anselmetti, J. Mattay, submitted.