DPG Phi
Verhandlungen
Verhandlungen
DPG

Regensburg 2010 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Downloads | Hilfe

DY: Fachverband Dynamik und Statistische Physik

DY 5: Statistical Physics of Biological Systems II (joint session of BP + DY)

DY 5.8: Vortrag

Montag, 22. März 2010, 16:15–16:30, H45

Long-range protein coupling mediated by critical low-energy modes of tubular lipid membranesSylvain Monnier1,3, Sergei B. Rochal2, •Andrea Parmeggiani3, and Vladimir L. Lorman11LPTA, CNRS, University of Montpellier II, 34095 Montpellier, France — 2Physical Department, South Federal University, 344090 Rostov-on-Don, Russia — 3DIMNP, CNRS, University of Montpellier II, 34095 Montpellier, France

Tubular lipid membranes (TLMs) are nanoscopic cylindrical assemblies that play a fundamental role in many intracellular and intercellular processes like protein trafficking, signaling and organelle morphogenesis. TLMs can be generated by a sum of mechano-chemical actions, ranging from mechanical forces produced by motor proteins pulling at one TLM-end up to the specific chemical activity of membrane proteins.

We develop a theory of TLM instabilities under longitudinal force and pressure difference constraints. Two qualitatively different critical low-energy modes are shown to define the stability domain boundaries. The analysis allows to introduce a new framework describing TLM-protein coupling, adsorbed protein-protein interaction and protein cluster nucleation on a TLM. In particular, bare TLM mechanical instabilities strongly influence protein-TLM coupling and protein desorption from the TLM. Model predictions can be directly tested in experiments involving nanomechanical devices extracting TLM over a large spectrum of mechanochemical conditions.

100% | Mobil-Ansicht | English Version | Kontakt/Impressum/Datenschutz
DPG-Physik > DPG-Verhandlungen > 2010 > Regensburg