Regensburg 2010 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 10: Basic and Applied Medical Physics (Poster Session)
ST 10.2: Poster
Mittwoch, 24. März 2010, 16:00–17:00, H41
NMR Spectroscopy and Imaging of blood-dissolved hyperpolarized 129Xe — •Nadia Amor1, Kathrin Hamilton2, Markus Küppers1, Ulrich Steinseifer2, Thomas Schmitz-Rode2, Stephan Appelt3, and Bernhard Blümich1 — 1ITMC of RWTH Aachen University, Germany — 2AME of RWTH Aachen University, Germany — 3Research Center Jülich, Germany
Hyperpolarization (HP) of noble gases, e.g. 3He and 129Xe, as a means of increasing the signal by several orders of magnitude has been widely employed in NMR over the last decades [1]. The advantages of 129Xe are its solubility and the sensitive chemical shifts. Dissolved HP 129Xe has been of growing importance, especially since the introduction of the so-called "xenonizer" setups [2]. They consist of hollow fiber membranes in oxygenators allowing for efficient and continuous dissolution into carrier agents without formation of foams or bubbling, and have been proven to be feasible for HP 129Xe MRI [3].
The xenon dissolution process has been analyzed for various solvents including porcine blood in home-built xenonizer setups featuring different fibers. The deoxygenating effect of the xenonization on blood with defined oxygen levels could be monitored online spectroscopically. The results presented offer a more comprehensive understanding of the xenonizer and yield valuable information about xenon-blood interactions.
[1] B.M. Goodson, J. Magn. Res. 155, 157 (2002)
[2] D. Baumer et al, Angew. Chem. Int. Ed. 45, 7282 (2006)
[3] N. Amor et al, J. Magn. Res. 201, 93 (2009)