Regensburg 2010 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 14: Radiation Physics (Poster Session)
ST 14.2: Poster
Donnerstag, 25. März 2010, 14:45–15:15, H41
Dependence of RBE on tissue type and effect level — •Thomas Friedrich1, Thilo Elsässer1, Marco Durante1,2, and Michael Scholz1 — 1GSI Helmholtzzentrum für Schwerionenforschung, Planckstraße 1, 64291 Darmstadt — 2Technische Universität Darmstadt, Institut für Festkörperphysik, Hochschulstraße 6-8, 64289 Darmstadt
The relative biological effectiveness (RBE) is frequently applied to characterize the enhanced effect of ions compared to that of photons. Experiments and biophysical models suggest that RBE depends on both the induced effect level, and the radioresistance of a cell as e.g. parameterized by the ratio of the parameters α and β of the linear quadratic model. First, starting from in-vitro cell survival assays we show that there is a linear dependence of RBE on the β/α-ratio for different cell lines. This empirical finding is also confirmed by simulations within the framework of the Local Effect Model. Second, the strength of the established correlation decreases and finally vanishes with increasing dose. We discuss implications and arising questions with respect to therapy and radiobiology.