Regensburg 2010 – scientific programme

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ST: Fachverband Strahlen- und Medizinphysik

ST 7: Nuclear Magnetic Resonance: Frontiers and Applications (CPP and ST)

ST 7.9: Talk

Tuesday, March 23, 2010, 15:45–16:00, H48

Heparin-polynitroxide derivatives: biocompatible polarizing agents for dynamic nuclear polarization (DNP) — •Björn C. Dollmann¹, Andrei L. Kleschyov², Vasily Sen³, Valery Golubev³, Laura Schreiber⁴, Kerstin Münnemann¹, and Dariush Hinderberger¹ — ¹Max Planck Institute for Polymer Research, Mainz, Germany — ²Second Department of Medicine, Johannes Gutenberg University, Mainz, Germany — ³Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia — ⁴Johannes Gutenberg University Medical Center, Mainz, Germany

A versatile and biocompatible class of spin-labeled macromolecules was investigated by electron spin echo-detected (ESE) electron paramagnetic resonance (EPR), continuous-wave (CW) EPR, double electron-electron resonance (DEER) and dynamic nuclear polarization (DNP). These heparin macromolecules could be utilized for in vivo magnetic resonance imaging (MRI DNP enhanced) and EPR imaging (EPRI). The distance distributions of the spin labels were measured and compared with the crystallographic structure of heparin. All presented heparin-polynitroxides show reasonably high ¹H DNP enhancement factors up to E=−108. The heparin-polynitroxides intrinsically feature high dipolar electron spin-electron spin coupling frequencies ν_dd. Together with the finding that the best ¹H-signal enhancements are found in the low concentration region, this proves the influence of the anisotropic electron spin distribution on DNP in liquids at room temperature.