Dresden 2011 – scientific programme
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BP: Fachverband Biologische Physik
BP 10: Posters: Tissue Dynamics \& Developmental Processes
BP 10.13: Poster
Monday, March 14, 2011, 17:15–20:00, P3
Mechanics and Morphology of the Dorsal-Ventral compartment boundary in the developing wing of the fly — •Maryam Aliee1, Constanze Teichman2, Katharina Landsberg2, Jens Röper2, Christian Dahmann2, and Frank Jülicher1 — 1Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany — 2Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
During the development of tissues cells organize into distinct compartments of different cell lineages. The interfaces between these compartments, called compartment boundaries, maintain straight and sharp morphologies. An important model system to study the morphology of compartment boundaries during development is the wing disc of the fruit fly Drosophila where two such boundaries exist: the anterior-posterior boundary and the dorsal-ventral (DV) boundary.
Here, we discuss general physical mechanisms by which compartment boundaries are shaped during the growth phase. Using a vertex model to describe cell mechanics in a growing tissue, we show that the roughness of the compartment boundary can be controlled by increased cell bond tension along the boundary. In addition a locally reduced cell division rate near the boundary leads to an effective interfacial tension and thereby reduced boundary roughness. We compare our results with the shape and mechanics of the DV boundary at different times during the fly wing development. We analyze the role of increased cell bond tension in the morphology of DV boundary and we speculate about the role of localized reduction in cell proliferation.