Dresden 2011 – scientific programme
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BP: Fachverband Biologische Physik
BP 22: Physics of Cells I
BP 22.3: Talk
Wednesday, March 16, 2011, 15:45–16:00, ZEU 250
Influence of cell shape on organelle organization — •Nina Malchus1 and Matthias Weiss1,2 — 1DKFZ c/o BIOQUANT, Heidelberg, Germany — 2University of Bayreuth, Bayreuth, Germany
Cells within a tissue often display a well-defined geometry in contrast to culture cells that adopt a wide variety of phenotypes. Using patterned substrates, we have forced cells into distinct geometries and examined the subcellular organization of organelles. To this end, we quantified the positions and shapes of organelles like the nucleus and the Golgi apparatus and determined correlations of these features within an ensemble of cells and in single cells as a function of time. In particular, we find that positions and sizes of organelles show fairly large varitions in an ensemble of cells despite a common geometry and symmetry-dependent correlations between features of different organelles.