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BP: Fachverband Biologische Physik
BP 23: Biopolymers and Biomaterials III (with CPP)
BP 23.5: Vortrag
Mittwoch, 16. März 2011, 16:00–16:15, ZEU 260
Transport of a semiflexible filament in a network — •Teresa Bauer1, Felix Höfling2, Erwin Frey1, and Thomas Franosch3 — 1Arnold Sommerfeld Center (ASC) for Theoretical Physics and Center for NanoScience (CeNS), Fakultät für Physik, Ludwig-Maximilians-Universität München, Germany — 2Max-Planck-Institut für Metallforschung, Stuttgart and Institut für Theoretische und Angewandte Physik, Universität Stuttgart, Germany — 3Institut für Theoretische Physik, Universität Erlangen-Nürnberg, Germany
The cytoskeleton of a cell is comprised of a network of various biopolymers. A prominent example is the filamentous actin, a semiflexible polymer studied extensively also in vitro. The transport of a single semiflexible filament in a strongly entangled network is highly directed along the confining tube formed by the surrounding network.
We have investigated the dynamics of a semiflexible filament in a plane in the presence of immobilized obstacles mimicking the constraints of the crosslinked network. The inextensibility constraints are encoded via a bead-rod-algorithm extended by a suitable collision rule and extensive simulations are performed. In particular we quantify the translational and rotational diffusion investigated for a broad density range and visualize the dynamics using representative animations. Furthermore we discuss issues of numerical stability.