Dresden 2011 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 33: Biological Machines \& Motor Proteins
BP 33.8: Vortrag
Freitag, 18. März 2011, 12:30–12:45, ZEU 250
Computational/Genetic approach characterizes the construction of the Drosophila ear — •Björn Nadrowski1,2, Thomas Effertz2, and Martin Göpfert2 — 1Theoretische Physik, Universität des Saarlandes, Campus E2.6, 66123 Saarbrücken — 2Abt. Zelluläre Neurobiologie, Universität Göttingen, MPI für Experimentelle Medizin, Hermann-Rein-Str. 3, 37075 Götingen
Hearing relies on dedicated mechano-electrical transduction (MET) channels that convert stimulus forces into electrical signals. We present a physical model hat quantitatively links ion channel mechanics and movements of molecular adaptation motors to the dynamics of the entire ear. We fit the model parameters to data obtained from both wild-type and mutant flies. We show that the experimental data obtained in the absence of NompC (a candidate MET gene), can be interpreted as the absence of a transduction channel in a transducer system that consists of two parallely arranged channel populations, one of them constituted by NompC. We further show evidence that NompC might be specifically needed to detect low stimuli amplitudes (i.e. sound stimuli), whereas the other channel population might serve for the detection of wind and/or gravity.