Dresden 2011 – scientific programme
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BP: Fachverband Biologische Physik
BP 4: DNA \& DNA Enzymes
BP 4.1: Invited Talk
Monday, March 14, 2011, 14:00–14:30, ZEU 260
Single-molecule detection of DNA repair in real-time — •Terence Strick1, Kevin Howan1, Nigel Savery2, Seth Darst3, and MM2M FP7 Consortium4 — 1CNRS Institut Jacques Monod Paris, France — 2University of Bristol, UK — 3Rockefeller Institute, NY, USA — 4Erasmus Univ., Rotterdam
We describe the bottom-up reconstruction of DNA repair pathways using single-molecule nanomanipulation methods. This allows us to observe in real-time the initial steps of DNA repair and build up kinetic models for repair processes. We discuss a variety of DNA repair systems and show in which ways these systems are mechanosensitive or not.