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BP: Fachverband Biologische Physik

BP 5: Tissue Dynamics \& Developmental Processes

BP 5.1: Hauptvortrag

Montag, 14. März 2011, 14:00–14:30, ZEU 250

Are biomechanical changes necessary for tumor progression? - The impact of cell mechanics on cancer development — •Mareike Zink, Anatol Fritsch, Tobias Kießling, K. David Nnetu, Steve Pawlizak, Franziska Wetzel, and Josef Käs — Abteilung Physik der weichen Materie, Fakultät für Physik und Geo-wissenschaften, Universität Leipzig, Leipzig, Germany

With an increasing knowledge in tumor biology an overwhelming complexity becomes obvious which roots in the diversity of tumors and their heterogeneous molecular composition. Nevertheless in all solid tumors malignant neoplasia, i.e. uncontrolled growth, invasion of adjacent tissues, and metastasis, occurs. Physics sheds some new light on cancer by approaching this problem from a functional, materials perspective. Recent results indicate that all three pathomechanisms require changes in the active and passive cellular biomechanics. Malignant transformation causes cell softening for small deformations which correlates with an increased rate of proliferation and faster cell migration. The tumor cell's ability to strain harden permits tumor growth against a rigid tissue environment. A highly mechanosensitive, enhanced cell contractility is a prerequisite that tumor cells can cross its tumor boundaries and that this cells can migrate through the extracellular matrix. Insights into the biomechanical changes during tumor progression may lead to selective treatments by altering cell mechanics. Such drugs would not cure by killing cancer cells, but slow down tumor progression with only mild side effects and thus may be an option for older and frail patients.