Dresden 2011 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 9: Posters: DNA \& DNA Enzymes

BP 9.1: Poster

Montag, 14. März 2011, 17:15–20:00, P3

Formation of DNA Tubes and Attachment of Nanoparticles — Matthew Wiens, Awadesh Dwivedi, Nora Haufe, •Anja Henning, and Michael Mertig — Professur für Physikalische Chemie, Mess- und Sensortechnik, TU Dresden, 01062 Dresden

Synthesizing cylindrical nanostructures is an important goal in supramolecular chemistry, material science and nanotechnology. DNA is one of the most promising materials for such structures since its sequence can be designed to self-assemble into tubular structures through complementary base pairing. Different approaches have been reported showing DNA tube generation from either single stranded DNA or DNA building blocks, so called tiles [1]. Most of these methods have the drawback that side products such as 2D lattices are formed and the length of the structures periodically extend over tens of micrometers.

We used two-dimentional DNA origami procedure similar to Douglas et al. in order to create a six helix bundle with a well defined geometry [2, 3]. The design provides binding sites in periodic distances for functionalized nanoparticles. This is a promising feature for possible applications of future nanoelectronic and -photonic devices or a template for the investigation of biomolecules.

[1] Sharma et al., Science 323, 112-116 (2009) [2] Rothemund, Nature 440, 297-302 (2006) [3] Douglas et al., PNAS 104, 6644-6648 (2007)