Dresden 2011 – wissenschaftliches Programm

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 35: Poster: Micro- and Nanofluidics

CPP 35.18: Poster

Mittwoch, 16. März 2011, 17:00–19:00, P2

On-chip realization of mixing and demixing nanoparticles using dielectrophoresis — •Martina Everwand, Dario Anselmetti, and Jan Regtmeier — Experimental Biophysics and Applied Nanoscience, Faculty of Physics, Bielefeld University, Germany

On-chip applications using microchannels are a very fast growing field of research. Point of care diagnostics or miniaturization of separation techniques are only two examples.

One distinct feature of microchannels is the laminar flow so that mixing of liquids and analytes is only driven by diffusion. Whereas a number of applications rely on that characteristic, procedures with different reaction partners are prohibitively slow. In order to investigate controlled reactions in a microfluidic device active mixing procedures are of key importance. In contrast to batch injection and detection strategies, which is a sequential process, and therefore very time consuming we explored continuous flow separations as one possibility to realize high throughput analysis, which allow further integration of functionalities up- or downstream of the separation.

Here, we present a continuous-flow application using electrodeless dielectrophoresis for efficient mixing and separation of 20 nm and 100 nm beads. A nano-microfluidic device was used with a constriction that reduces the channel height. The benefit of this device is that the parameters according to which the separation or mixing is performed can be adopted in real time while the device is running by tuning applied AC and DC voltages. This label-free technique is very promising for manipulation of polarizable biomolecules in continuous flow mode.