Dresden 2011 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 43: Nanoparticles and Composite Materials I
CPP 43.10: Vortrag
Donnerstag, 17. März 2011, 16:45–17:00, ZEU 222
Gold Nanoparticles Decorated with Oligo(ethylene glycol) Thiols: Protein Resistance from Single Particle to Superlattice — •Fajun Zhang1, Maximilian W. A. Skoda2, Robert M. J. Jacobs3, Claire Pizzey4, and Frank Schreiber1 — 1Institut für Angewandte Physik, Universität Tübingen, Tübingen, Germany — 2ISIS, Rutherford Appleton Laboratory, Chilton, UK — 3Department of Chemistry, Chemistry Research Laboratory, University of Oxford, UK — 4Diamond Light Source, UK
Self-assembled monolayers (SAM) with oligo(ethylene glycol) (OEG) termination are of great importance in biomedical applications due to their protein resistance property. We have successfully prepared OEG-thiol decorated gold colloids and studied various interactions, stability and aggregation kinetics of colloid in the mixture with proteins by SAXS and UV-vis spectroscopy [1]. The results show that the protein resistance of the OEG SAM is maintained at curved interfaces. It is also shown that the colloids lose their stability and form aggregates upon adding protein above a critical concentration due to the depletion-attractive interaction [1]. The stability of the mixtures of the functionalized AuNP and proteins in solution strongly depends on the nature of added salts, which follow the Hofmeister series [1]. Further, a superlattice of SAM coated AuNP on a substrate is obtained, which provides a new model interface with protein resistance property. SAXS measurements indicate an FCC structure of the superlattice.
[1] F. Zhang, et al. J. Phys. Chem. A 2007, 111, 12229. Eur. Biophys. J. 2008, 37, 551. J. Phys. Chem. C 2009, 113, 4839.