Dresden 2011 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
CPP: Fachverband Chemische Physik und Polymerphysik
CPP 44: Micro- and Nanofluidics I
CPP 44.1: Vortrag
Donnerstag, 17. März 2011, 14:00–14:15, ZEU 160
Enantioselective separation by an asymmetric flow profile — •Florian J. Lorenz1, Lukas Bogunovic1, Ralf Eichhorn2, Dario Anselmetti1, and Jan Regtmeier1 — 1Bielefeld University, Bielefeld, Germany — 2NORDITA, Stockholm, Sweden
The pharmaceutical use of homochiral chemicals is of great interest, because they have different physiological responses in organisms, because of the chiral selectivity in biological systems.
Since abiotic synthesis strategies often render an enantiomeric mixture (so called racemate), the racemate-splitting into pure enantiomers is one of the main challenges. To date, however, this is often realized by chromatography- and electrophoresis-separation-methods, with the great disadvantage that specifically designed chemical selectors are needed.
We present an alternative physical method, selector-free and continuously working, to separate enantiomers at the micrometer scale. It is based on an asymmetric flow profile within a microfluidic Lab-On-a-Chip (LOC) platform with broken spatial symmetry. We could demonstrate that the enantiomers are separated within the micro-channel and can be harvested in different reservoirs at the end.
Currently we explore the possibility to further miniaturize those devices for nanoscale separation of chiral molecules.