Dresden 2011 – wissenschaftliches Programm
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HL: Fachverband Halbleiterphysik
HL 85: Poster Session II
HL 85.58: Poster
Donnerstag, 17. März 2011, 18:00–21:00, P4
Biofunctionalization of ZnO nanowires for DNA sensory applications — Ulrich Christian Schröder1, •Martin Gnauck1, Robert Möller2, Bettina Rudolph2, Wolfgang Fritzsche2, and Carsten Ronning1 — 1Institute of Solid State Physics, University of Jena, Max-Wien-Platz 1, D-07743 Jena — 2Institut für Photonische Technologien e.V., Albert-Einstein-Straße 9, D-07745 Jena
In recent years, DNA detecting systems have received a growing interest due to promising fields of application like DNA diagnostics, gene analysis, virus detection or forensic applications[1]. Nanowire-based DNA biosensor allows both miniaturization and easy continuous monitoring of a detection signal by electrical means. The label free detection scheme based on electrochemical changes of the surface potential during immobilization of specific DNA probes was heretofore mainly studied for silicon [2]. In this work a surface decoration process with bifunctional molecules known as silanization was applied to VLS-grown ZnO nanowires which both feature a large sensitivity for surface modification, are biocompatible and easy to synthesize as well. Successfully bound DNA was proved by fluorescence microscopy. Dielectrophoresis (DEP) was chosen and optimized for quickly contacting the ZnO nanowires. Furthermore, electrical signal characterization was performed in preparation for DNA sensory applications.
[1] Sassolas, A.; Leca-Bouvier, B. D. & Blum, L. J., Chemical Reviews, Amer Chemical Soc, 2008, 108, 109-139; [2] Corso, C. D.; Dickherber, A. & Hunt, W. D., Elsevier Advanced Technology, 2008, 24, 805-811