Dresden 2011 – wissenschaftliches Programm

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MS: Fachverband Massenspektrometrie

MS 8: New Mass Spectrometric Methods and Technical Developments

MS 8.6: Vortrag

Donnerstag, 17. März 2011, 12:00–12:15, GÖR 229

Analytical detection of explosives and illicit, prescribed and designer drugs using proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS) — •Bishu Agarwal¹, Fredrik Petersson¹, Simone Jürschik¹, Philipp Sulzer², Alfons Jordan², Tilmann D. Märk^1,2, Peter Watts³, and Chris A. Mayhew³ — ¹Institut für Ionenphysik und Angewandte Physik, Universität Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria — ²IONICON Analytik GmbH, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria — ³School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 4TT, UK

This work demonstrates the extremely favorable features of Proton Transfer Reaction Time-of-flight Mass Spectrometry (PTR-TOF-MS) for the detection and identification of solid explosives, chemical warfare agent simulants and illicit, prescribed and designer drugs in real time.

Here, we report the use of PTR-TOF, for the detection of explosives (e.g., trinitrotoluene, trinitrobenzene) and illicit, prescribed and designer drugs (e.g., ecstasy, morphine, heroin, ethcathinone, 2C-D). For all substances, the protonated parent ion (as we used H3O+ as a reagent ion) could be detected, providing a high level of confidence in their identification since the high mass resolution allows compounds having the same nominal mass to be separated. We varied the E/N from 90 to 220 Td (1 Td = 10-17 Vcm-1). This allowed us to study fragmentation pathways as a function of E/N (reduced electric field). For a few compounds rather unusual E/N dependencies were also discovered.