Berlin 2012 – scientific programme

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BP: Fachverband Biologische Physik

BP 10: Biopolymers and Biomaterials (with CPP)

BP 10.7: Talk

Tuesday, March 27, 2012, 11:30–11:45, H 1058

Biocompatibility of Fe₇₀Pd₃₀ ferromagnetic shape memory films for cell actuation — •Uta Allenstein¹, Yanhong Ma², Ariyan Arabi-Hashemi², Stefan G. Mayr², and Mareike Zink¹ — ¹Division of Soft Matter Physics, Institute for Experimental Physics I, University of Leipzig, Germany — ²Leibniz-Institut für Oberflächenmodifizierung e.V., Translationszentrum für Regenerative Medizin and Fakultät für Physik und Geowissenschaften, Universität Leipzig, Germany

Ferromagnetic shape memory alloys (FSMAs) are a very promising and highly applicable class of smart functional materials which show various interesting features, such as the induction of large reversible strains of several percent due to an external magnetic field at a moderate stress. These properties support the application as actuators or valves in biomedical devices, as well as bone prostheses. Of course in vivo implantation demands good biocompatibility and adhesion of different tissues to the material. Thus, our study investigated the cellular response in contact with single crystalline Fe₇₀Pd₃₀ FSMA films on MgO substrates. The adhesive properties as well as the viability and proliferation of different cell types where tested on the substrates and tuned by coating the substrates with different adhesive materials, such as Fibronectin, Laminin and Poly-L-Lysin. Tests were carried out with NIH 3T3 mouse fibroblasts, MCF 10A human epithelial cells and primary HOB human osteoblasts. We show that these three cell types obtain the ability to adhere and proliferate well on Fe₇₀Pd₃₀ FSMA substrates, demonstrating good biocompatibility of the films.