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BP: Fachverband Biologische Physik
BP 10: Biopolymers and Biomaterials (with CPP)
BP 10.9: Talk
Tuesday, March 27, 2012, 12:00–12:15, H 1058
Superparamagnetic Iron Oxide Nanoparticles as Radiosensitizer for Radiation Therapy — •Anja Sommer1, Stefanie Klein1, Luitpold Distel2, and Carola Kryschi1 — 1Department of Chemistry and Pharmacy, Institute of Physical Chemistry I, University of Erlangen, Egerlandstr. 3, 91058 Erlangen, Germany — 2Department of Radiation Oncology, University of Erlangen, Universitaetsstr. 27, 91058 Erlangen, Germany
Superparamagnetic iron oxide nanoparticles (SPION) have been widely used experimentally for numerous in vivo applications such as magnetic resonance imaging (MRI) contrast enhancement, hyperthermia and targeted drug delivery. we present the synthesis of surface-stabilized ultrasmall superparamagnetic iron oxide nanoparticles. In this contribution, we will report on functionalized SPION with sizes between 4 and 15 nm which were synthesized by alkine coprecipitation or thermal decomposition and subsequently coated with biocompatible acids. The differently stabilized SPION were fully characterized using HRTEM, XRD, SQUID, FTIR and Raman spectroscopy, XPS, TGA-MS and TGA-IR coupling and zeta potential measurements. Furthermore we present studies about their biocompatibility for cancer cell lines and their potential as radiosensitizer in radiation therapy.